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The split-dose protocol used by many compounding telehealth clinics is intended to smooth the Cmax peak that drives nausea: tirzepatide has a roughly 120-hour half-life (StatPearls pharmacokinetics) and once-weekly dosing produces a peak 8 to 72 hours post-injection where GI side effects cluster
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In addition, it helps our body convert fat and carbohydrates to energy, however if your B12 is low, this can severely hinder this process
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