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Unlike the cardiac samples, we observed several HFpEF-specific clusters in our UMAP, including a cluster of periportal-like hepatocytes (highlighted in Figure S7A-B ) and the cluster of proliferating cells that was significantly enriched in HFpEF in our cell type composition analysis ( Figure S7A, B )
The most characterized transcription factors involved in the regulation of EMT include snail family transcriptional repressor (SNAIL)1, zinc finger E-box binding homeobox 1 (ZEB1), and twist family bHLH transcription factor 1 (TWIST1) [33, 34]
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2025 Jan 1;21(2):725-744
Sekmen AH, Ozgur R, Uzilday B, Turkan I
GLP-Squared is a single compound formulation from licensed 503A compounding pharmacies that co-activates GLP-1 and GIP receptors in integrated balance
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