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Some researchers have explored its potential in breaking the cycle of pain, insomnia, and increased pain sensitivity though clinical evidence in humans is still preliminary

This is typically in response to POMC stimulation by hormones such as leptin

Vitamin B12 may also help with fatigue and weakness, especially in those with deficiency

PLoS One (2016) 11(7):e0160221

For appetite considerations: Because ipamorelin acts on the ghrelin receptor, some ghrelin-mimetic effects (including mild appetite stimulation) are theoretically possible, though ipamorelin is considered relatively mild on this front compared with GHRP-6