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For example, in clinical trials of semaglutide 2.4 mg (Wegovy), nausea occurred in approximately 44% of patients, while rates for tirzepatide and other GLP-1s vary: Nausea : Often described as mild queasiness, particularly after eating, though some patients experience more pronounced nausea Bloating and abdominal fullness : A sensation of delayed digestion or food sitting heavily in the stomach Changes in bowel habits : Constipation affects approximately 15-30% of patients (varying by medication and dose), while some experience diarrhea or alternating patterns [1] [4] Decreased appetite : Beyond simple fullness, many report a fundamental shift in food thoughts, with reduced cravings and less mental preoccupation with eating Some patients report fatigue or low energy , particularly during the initial weeks

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Over-the-counter antidiarrhoeal medications such as loperamide may be considered for symptomatic relief, but patients should consult their GP or pharmacist before use

Tchang thinks this is the completely wrong approach for retention and lifetime value: In weight - loss maintenance, people just dont want to feel like they are in a program or that theyre patients still, that theyre being medicalised