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A statistically significant increase in thyroid C-cell adenomas was observed in male rats (0.5 mg/kg) and female rats (0.15 mg/kg), and a statistically significant increase in thyroid C-cell adenomas and carcinomas combined was observed in male and female rats at all doses examined

Cagrilintides monotherapy evidence reaches only Phase 2: a dose-finding trial established a doseresponse on bodyweight versus placebo and versus an active comparator

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L-carnitine is an amino acid derivative that is commonly supplemented to support cardiac health and promote energy metabolism in veterinary and over-the-counter diets

Ten trials 13,14,2632 had sufficient data for the meta-analysis (n=366 treatment, n=359 control), and five trials 15,26,3335 were excluded from quantitative synthesis due to incomplete or non-extractable data