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A second mechanism of PKA-independent incretin potentiation of glucose-stimulated insulin secretion (GSIS) involves cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) EPAC2
Keep in mind semaglutide and tirzepatide have shown a clear benefit for reducing cardiovascular disease including heart attack and stroke and they usually only lower LDL cholesterol by 4-8% This is more than double that reduction
Receptor activation raises intracellular cAMP, which triggers calcium influx and GH exocytosis
[PMID: 29667297] PubMed record related to this compound for laboratory literature review
explored a possible pharmacodynamic interaction between GLP1 that decelerates gastric emptying and the prokinetic drugs metoclopramide, domperidone, cisapride and erythromycin in nine healthy males [28]
