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When a low dose of aspirin is administered orally (most commonly 81 mg), its context-sensitive drug disposition via the portal circulation combined with the difference in IC50 values for COX-1 vs COX-2 both contribute significantly to the high selectivity by which low dose oral aspirin inhibits platelet COX-1 vs other COX-2 found in other nucleated tissues such as the vascular endothelium (Pedersen & FitzGerald, 1984
More recent work has examined boron-rich derivatives (PMID 30168238) and PET-imaging-relevant peptidomimetic derivatives (PMID 30282322), broadening the SAR landscape around the original compound
Mitochondrial sirtuins in Parkinson's Disease
Although the findings are encouraging, Wellberg said much more research is needed to determine whether GLP-1 drugs could be used to prevent cancer or serve as part of cancer treatment strategies
In a rat model of ischemic stroke, administration of the herbal compound Salvia miltiorrhiza extract modulated gut microbiota composition, reduced infarct size, and decreased markers of inflammation and oxidative stress, indicating a gut-mediated neuroprotective effect (Wu J
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