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Animal model studies demonstrate a biphasic response curve where low micromolar concentrations (110 M) produce maximal NF-B inhibition, while concentrations above 50 M show diminishing returns and, in some tissue types, paradoxical pro-inflammatory signaling
Functional medicine clinicians also report reduced IBS symptoms and lower calprotectin levels in patients using oral BPC-157
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Its primary mechanism is increasing VEGF expression (vascular endothelial growth factor), which promotes new blood vessel growth at injury sites
