Die Folge knnen verringerte Leistungsfhigkeit, aber auch ernste Erkrankungen sein
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Specifically, in-house donors exhibited lower NAD + , NADH and NADP + levels (on average 3.2, 0.47 and 1.6 uM lower, respectively) but higher NADPH levels (on average 0.88 uM) compared to biobank samples (Supplementary Figure 2a)
IGF1R autophosphorylation also recruits Shc, which leads to Grb2/SOS/Ras activation and downstream ERK1/2 phosphorylation