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They do not account for hormonal shifts that increase cravings and fat storage
Weight loss at 48 weeks was clearly dose-dependent
Tirzepatide for managing overweight and obesity - Technology appraisal guidance TA1026
Flanagan JL, Simmons PA, Vehige J, Willcox MD, Garrett Q
Their ability to lower serum cholesterol and triglyceride levels, reduce liver fat content, and decrease the highly inflammatory visceral fat means that while these drugs are producing weight loss, theyre making a big impact on inflammation and metabolism
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