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Key Milestones Timeline Eli Lillys Strategic Context Retatrutides development occurs within Eli Lillys broader metabolic disease portfolio, which also includes tirzepatide (approved as Mounjaro for type 2 diabetes and Zepbound for obesity) and orforglipron (an oral GLP-1R agonist in Phase 3 development)

Statements Author contributions XT: Writing original draft, Writing review & editing, Funding acquisition

17 With immune-mediated disorders, TPE can alter the T-helper type 1 and T-helper type 2 cell ratio by increasing the predominance ratio from Th-2 to Th-1, thereby boosting humoral immune response and modulating cellular immunity

Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINA-T2D trial