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Before the company applied to the FDA for the drug to be approved for obesity, Knudsen and her colleagues 'developed a new methodology to show how [GLP-1] drugs exert their effect on the brain by working on the circumventricular organs and communicating further into the hypothalamus, among other effects.' This was designed to illustrate how GLP-1 worked in 'well- defined neurons in the hypothalamus, in the hindbrain, and in the reward centers.' Their rationale for developing the method was because 'It was very important to show that these medicines work on defined brain circuits and not ones that may be related to psychiatric or cardiovascular side effects, for example' (Nair

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Get 15 to 30 minutes of bright light exposure within one hour of waking Natural sunlight is ideal, but a 10,000 lux light therapy box works for Canadian winters Dim lights in your home starting two hours before bed Use blue light blocking glasses if screens are unavoidable in the evening Keep your bedroom completely dark during sleep (blackout curtains recommended) Exercise Timing Considerations Physical activity improves sleep quality, but timing matters

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