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The effects became measurable after 20 weeks of treatment, providing objective biochemical confirmation of what patients reported experiencing
The SURMOUNT-1 trial demonstrated mean body weight reduction of 20.9% at 72 weeks on tirzepatide 15mg weekly versus 3.1% placebo
Animal studies using doses equivalent to human therapeutic levels showed fetal organ malformations and growth restriction, prompting FDA pregnancy category warnings
Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
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