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Despite unanswered questions, health insurers should prepare for increasing interest in and demand for GLP-1s

Consistent with this use of a reporter mouse together with a number of validation approaches the GLP-1R was identified in chief cells, parietal cells and Brunners glands ( 125 I-labeled GLP-1 also demonstrated a strong signal in stomach parietal cells, basolateral epithelial cells in the duodenum, Brunners glands and the myenteric nerve plexus (Pyke et al., 2014)

1,2 Oral Semaglutide Safety and Tolerability in Context Overall Safety and Tolerability of Oral Semaglutide The safety and tolerability of GLP-1RAs are well characterized from a large number of clinical trials 35,36 and these agents have been used in clinical practice since 2005