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Earlier recommendations advocated treatment of the cobalamin C defect with a combined approach that utilizes vitamin B12 plus betaine to provide a substrate for the conversion of homocysteine into methionine through betaine-homocysteine methyltransferase, and folic acid to enhance the remethylation pathway (164)

Mechanistic comparison: using full-length hGH as a reference to contextualize the effects of the AOD9604 fragment without interference from pleiotropic endocrine pathways

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Cyanocobalamin is the most widely available synthetic form, is shelf-stable, and is FDA-approved for treating B12 deficiency

Subsequently, the solution was subjected to dialysis using a dialysis bag with a molecular weight cutoff of 800014,000 Da