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For assessment of macrophage activation and cytokine release, lipopolysaccharide (LPS) (Sigma-Aldrich) was diluted in VPM to a concentration of 100 ng/mL

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Research shows that GLP-1 medications like semaglutide can lead to dramatic early weight loss, but plateaus typically occur after several months, requiring a new, physician-guided approach for continued success

Here's how the two groups compared on reaching key weight loss milestones: Waist circumference also shrank more with tirzepatide: an average of 18.4 cm (about 7 inches) compared to 13.0 cm (about 5 inches) with semaglutide.[1] "The SURMOUNT-5 head-to-head results demonstrated tirzepatide led to greater weight reduction compared to semaglutide," said Dr