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GLP-1: GLP-1(7-36) & GLP(9-36) GLP-1 is an endocrine peptide hormone synthesized in multiple locations including: 1) L-cells located in the intestinal mucosa, 2) -cells found in the pancreatic islet, and 3) central neurons residing in the nucleus of the solitary tract, a region regulating appetite and digestion (D'Alessio, 2016)

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The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail

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