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11-17 Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a novel class of medications for weight management that stimulate insulin secretion after an oral glucose load, inhibit the production of glucagon at high blood sugar levels, and decrease pancreatic -cell apoptosis

When stopping Semaglutide abruptly, some patients may experience mild to moderate weight gain

They work through overlapping mechanisms and combining them would significantly increase side effect risks without proven additional benefits

Based on significant preclinical data, large-scale clinical trials were initiated to test the efficacy of GLP-1R agonists on cardiovascular outcomes in various patient cohorts

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