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In particular, aerobic respiration by mitochondria (the powerhouses of the cell) leads to the production of ROS as oxygen is gradually converted into water

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And by the same token, if theres issues in methylation anywhere, not just MTHFR, but and the whole folate methionine cycle, were gonna see a compromised level of methyl donors being produced, which means histamine and methyltransferase doesnt have the conjugates to be able to clear histamine in the first place, so it is a bit of a wicked web to go down

Aging Cell 14(4):644-658