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GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds copper ions, forming a biologically active complex involved in tissue repair and skin remodeling processes

However, transfection of PD-related PINK1 mutants up-regulated TH and DA levels in dopaminergic neurons, making them vulnerable to oxidative stress [42]

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To combat oxidative stress, iPSCs employ a sophisticated antioxidant defense system, including superoxide dismutase and glutathione peroxidase, which are essential for protecting cells from ROS-induced damage [100]