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Phentermine and topiramate extended-release 22.5 mg/138 mg [a supra-therapeutic dose resulting in a phentermine and topiramate maximum concentration (Cmax) of 4-and 3-times higher than those at phentermine and topiramate extended-release 7.5 mg/46 mg, respectively] did not affect cardiac repolarization as measured by the change from baseline in QTc

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They are also looking for clarity, comfort, and trust

That might be able to guide the need for some individuals to consider newer therapies, which are more potent, in the future, he said

doi: 10.1016/j.freeradbiomed.2019.05.035 286 ValdsA.Ortega MorenoL.Rojo RelloS.OrduaA.BernardoD.CifuentesA