Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease
212,213,214 These DAMPs trigger gliotic responses, initially represented by migration of microglia and OPCs as described previously, and second, after the end of infarct expansion, reactive astrogliosis
Reinforcing this, a prior study elucidated the surge in MDA, coupled with a concomitant drop in antioxidants like GSH and SOD, in cardiac tissues under the duress of CLP-induced sepsis 50
These subtypes are not mutually exclusive
It would also be pertinent to include a cohort of neurotypical children in a similar study to compare any changes in glutathione levels and behaviors in that population with those of children with ASD