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A randomized controlled trial is a type of study where participants are randomly assigned to different treatments, which provides stronger scientific evidence

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Key features include: Persistent right upper quadrant pain lasting more than six hours Fever and systemic signs of infection Tenderness in the right upper abdomen that worsens during deep breathing Jaundice (yellowing of skin and eyes) if bile duct obstruction occurs Dark urine and pale stools Loss of appetite and general malaise Some patients may experience chronic cholecystitis , characterised by recurrent episodes of milder abdominal discomfort, bloating, and intolerance to fatty foods

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Nouwen A et al (2010) Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis