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Future long-term head-to-head RCTs assessing the GLP-1 analogues versus sitagliptin should be designed to provide a definitive answer regarding the place of the two classes of agents in the treatment algorithm

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GLP-1 drugs for diabetes and weight-loss management have become a meaningful and growing component of pharmacy spend, and will continue to impact employer pharmacy costs in 2026. When employer healthcare costs rise, companies almost always shift more costs onto their workers in the form of premiums that employees pay out of their paychecks or various cost-sharing methods like co-payments or deductibles