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Coyle, Darren Rattigan, Kate Hourigan, Colin Davenport, Tommy Kyaw-Tun, John H McDermott, Seamus Sreenan Connolly Hospital, Blanchardstown, Dublin C-peptide is a surrogate marker for pancreatic beta cell function, with lower levels seen in type 1 diabetes mellitus (T1D) compared to other forms of diabetes

This enzyme relies entirely on a steady supply of GSH to catalyze the reduction of hydrogen peroxide (H2O2) and lipid peroxides into water and harmless alcohols

To date, however, no large DPP4i CVOT has shown independent renoprotective effects in T2MD patients with CKD