SURMOUNT-2, in participants with type 2 diabetes, showed 12.8% and 14.7% weight loss at 10mg and 15mg respectively
Primarily prescribed for managing Type 2 diabetes, it has since gained extensive off-label use as a weight-loss medication
It also inhibits TGF-beta1, a cytokine that promotes fibrosis
Tirzepatide and semaglutide, in rare cases, may cause serious side effects, which include: Pancreatitis (inflammation of the pancreas) Vision problems Kidney problems, including kidney failure Gallbladder problems Pulmonary aspiration during sedation or procedures (tell your healthcare provider you use tirzepatide or semaglutide if you are planning any medical procedures) Before using tirzepatide or semaglutide, tell your healthcare provider about all of your medical conditions, medical history, and family history
Lifestyle Adjustments: Essential but often insufficient on their own, particularly for women facing severe metabolic and hormonal imbalances that impede weight loss