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If a dose increase causes intolerable GI symptoms, the Phase 2 protocol explicitly permitted returning to the prior dose level and waiting a full 4 weeks before re-attempting escalation
The recommended starting dose is 1 tablet of 3 mg per day for 30 days
Its prevalence is increasing worldwide, and, like obesity, it affects progressively younger populations compared to the past, with potentially greater impact on chronic complications
The -aminoisobutyric acid (Aib) residue at position 1 confers resistance to N-terminal peptidase cleavage
12.31.19 2019 year-end total adverse events 1,244 total cases, including 22 deaths
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