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the progression from 0.5 mg to 1.5 mg or 2.0 mg spans 8 to 12 additional weeks to ensure tolerability

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After 12 weeks of twice-daily application over the entire face, evaluation by visiometry revealed a significant reduction in two skin-roughness parameters (R2 and R3) among the women in the L-carnitine group, reflecting a visible improvement in skin texture and a decrease in wrinkles compared with the placebo

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