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It works by inhibiting the NNMT enzyme, which is associated with fat storage, insulin resistance, and reduced cellular energy
While people who are vegetarian or vegan may not get Vitamin B12 as it is not found naturally in foods such as fruits, vegetables and grains
In general, vitamin B12 supplements are not considered harmful
Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]
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