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Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3

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181 Further, the activity of G6PD is also repressed by aspirin casing acetylation of G6PD to decrease the activity of G6PD and the generation of NADPH, and by RRx-001, a novel clinical-stage chemosensitizer and radiosensitizer, which exerts antiproliferative effects in human tumor cells

While these compounds aren't FDA-approved for GERD treatment, controlled trials have demonstrated statistically significant reductions in esophageal inflammation and symptom frequency compared to placebo

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