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Age is another important factorolder adults naturally experience sarcopenia (age-related muscle loss) and may be more vulnerable to further muscle decline during pharmacologically induced weight loss
When retatrutide becomes available, the candidate criteria will likely be similar to other weight loss medications
However, because MOTS-c affects glucose metabolism, patients on diabetes medications require careful monitoring and potential dose adjustments during the protocol
PMID 24630777
Nevertheless, oral semaglutide requires administration 30 minutes before food or beverages with only 4 ounces of water [24]
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