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RCT in British Journal of Dermatology is the strongest single piece of human evidence and it tested a multi-ingredient cosmetic anti-ageing product, not isolated GHK-Cu 10

(2002) Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy

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Another unique aspect of CHIVA is that rather than attempting to completely eliminate all reflux, as in other surgical methods, CHIVAs goal is interruption of venous hypertension at its source, higher up in the venous system (Mowatt-Larssen 2010