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The results paved the way for liraglutide, branded as Saxenda, to be approved in the US as a once-a-day subcutaneous injection in December 2014 and in Europe in 2015 for the treatment of chronic weight management combined with a reduced calorie diet and increased physical exercise (Molteni, Chen)
Although such strategies are promising, the evidence base remains limited, and additional studies, including clinical trials, are needed to establish feasibility, safety, and durability of benefit in humans
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Its method of action involves binding to ghrelin receptors, specifically the Growth Hormone Secretagogue Receptor (GHS-R1a), located in the hypothalamus and pituitary gland
