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This guide covers: What compounding pharmacies are and why they exist How semaglutide compounding works The difference between 503A and 503B facilities Quality standards and testing requirements FDA oversight of compounding How to evaluate a compounding pharmacys quality Red flags that indicate problematic providers What legitimate compounded semaglutide looks like Questions to ask before starting treatment Key Takeaways Compounding is legal and regulated under FDA guidance, with specific rules for how pharmacies can produce semaglutide 503A pharmacies fill individual prescriptions and are primarily state-regulated 503B outsourcing facilities produce larger quantities under stricter FDA oversight and cGMP standards Semaglutide can be compounded because the brand-name products have been on the FDA drug shortage list Quality varies significantly between compounding facilities

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Humectants, typically present in amounts ranging from about 0.1% to about 5% by weight of the total composition include, but are not limited to, polyhydric alcohols such as glycerol, polyalkylene glycols (e.g., butylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, and polyethylene glycol) and derivatives thereof, alkylene polyols and their derivatives, sorbitol, hydroxy sorbitol, hexylene glycol, 1,3-dibutylene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol, and mixtures thereof