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Revised: May 2025 PRINCIPAL DISPLAY PANEL - 1.5 mL Pen Carton NDC 0024-5869-03 Rx only Toujeo SoloStar (insulin glargine) injection For Single Patient Use Only 300 units/mL (U-300) For subcutaneous use only Solution for injection in a disposable insulin delivery device Do not remove insulin with syringe Always use a new needle Do not mix with other insulins Use only if solution is clear and colorless with no particles visible Use within 56 days after opening *Needles not included (see back panel) Three 1.5 mL prefilled pens Dispense in this sealed carton sanofi PRINCIPAL DISPLAY PANEL - 3 mL Pen Carton NDC 0024-5871-02 Rx only Toujeo Max SoloStar (insulin glargine) injection For Single Patient Use Only 300 units/mL (U-300) Adjusts by 2 units For subcutaneous use only Solution for injection in a disposable insulin delivery device Do not remove insulin with syringe Always use a new needle Do not mix with other insulins Use only if solution is clear and colorless with no particles visible Use within 56 days after opening *Needles not included (see back panel) Two 3 mL prefilled pens Dispense in this sealed carton sanofi Biological Products Related to Toujeo SoloStar Find detailed information on biosimilars for this medication

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doi: 10.3390/insects10080245 223 Nsslein-VolhardC

Possible causes: dead space accumulation (discussed above), inaccurate water volume at reconstitution (more water means more dilute, means more volume per dose, means fewer doses from the same amount of peptide), or air in the vial displacing solution