When the tumor volume reached approximately 200 mm, the mice were intravenously administered with Cy7.5-labeled NP4 at a dosage of 2 mg/kg
These refer to the activity of activation factors
As the essential eNOS cofactor tetrahydrobiopterin (BH 4 ) is susceptible for oxidation, a landmark study by David Harrison's group 62 was able to proof the concept that superoxide produced by the Nox may indeed trigger eNOS uncoupling in the experimental animal model of DOCA-salt hypertension

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