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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin in insulin-naive patients with type 2 diabetes (SUSTAIN 4): A randomized, open-label, parallel-group, multicenter, multinational, phase 3a trial

This weight loss has been attributed to semaglutides ability to lower food intake, diminish hunger, decrease preference for high-fat foods, and reduce cravings (Blundell et al., 2017)

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However, individual responses to any medication vary widely

Semaglutide causes a small average increase of around 1-4 beats per minute, while propranolol lowers heart rate