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Current evidence suggests the answer is yes

Taking both together may make it worse

SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks

Unfortunately, many never receive a root cause diagnosis for various reasons including the poor quality of tests for pernicious anemia, the incompetence and/or disinterest of many doctors in looking for a cause for the deficiency etc