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HQ-I values were calculated according to the mathematical formulas contained in the protocol of the United States Environmental Protection Agency (IRIS, 2011)
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However, unclear molecular mechanism of hepatic steatosis impedes the therapy of this hepatic steatosis
additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81
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