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The NIH reports that only about 10 micrograms of a 500-microgram oral supplement are actually absorbed in healthy people due to limitations of stomach acid and intrinsic factor

But for vegans, supplements are a must to avoid deficiency. Malabsorption-Related Deficiency Protocols Malabsorption-related B12 deficiency needs a special treatment

Once opened, it should generally be used immediately because it does not have the same protection against bacterial growth