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Retatrutide produces more gastrointestinal distress but also delivers more weight loss as a monotherapy

It differs from the native 70 residue growth factor by an arginine-for-glutamate substitution at position 3 and a hydrophobic 13 residue N-terminal extension, MFPAMPLLSLFVN, which is itself a residual fragment of the methionyl porcine growth hormone fusion partner used to express the protein in Escherichia coli

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High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

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