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Omics-based studies have increasingly identified convergent endometrial and systemic pathways, including defective decidualization, immune dysregulation, abnormal extracellular matrix remodeling, and perturbed inflammatory signaling, that distinguish these conditions from isolated implantation or pregnancy failure and motivate a shift from single-marker interpretations toward multi-layer endotyping

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When the same area receives repeated injections, scar tissue and lipodystrophy can develop beneath the skin surface, invisible to the eye but tangible to the touch

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