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Activation of FXR stabilizes the nuclear co-repressor (NcoR) at the NF-B response element on the IL-1 promoter, while decreasing the expression of TNF-, IL-1, IL-2, IL-6 and IFN- mRNA, thereby reducing the extent of inflammation (Vavassori et al., 2009)

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doi:10.1093/advances/nmac093

The most common protocols involve: Semaglutide microdose protocol: Starting at 0.05 mg weekly, holding for 4 weeks, then reassessing inflammatory markers before considering any adjustment

Together they support immune function, redox balance, detox pathways, and recovery from oxidative stress