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Additionally, endothelial cell damage disrupts vascular barrier function, leading to plasma component extravasation, causing renal interstitial edema, further compressing microvessels, increasing vascular resistance, and further deteriorating local perfusion status, resulting in synergistic dysfunction of structural and functional impairments [47]

Schirrmacher, V

Such differences suggest reduced CBS activity in the transsulfuration pathway and lower H 2 S production by this enzyme in mother and placental-fetal unit in severe IPTB cases

184 For the folate metabolism pathway, the NADP + -dependent dehydrogenase activity of MTHFD2 and MTHFD2L can be inhibited by inorganic phosphate

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