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Here, we could demonstrate that blocking zonulin with the specific antagonist larazotide acetate was sufficient to restore the impaired barrier function in intestinal organoid cultures exposed to complete fecal supernatants from CIA mice containing high zonulin levels

Tissue permeability After subcutaneous injection, AOD 9604 spreads to adipose tissue through local capillaries and avoids systemic distribution

Decreased CBF precedes the detectable changes of classical A and tau biomarkers, as well as brain atrophy, suggesting that reduced CBF could be a valuable biomarker in preclinical AD [138, 179]

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