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The researchers monitored the effect of FOXO4-DRI on a group of aged laboratory mice, noting a significant decrease in the number of senescent Leydig cells and a parallel increase in the concentration of testosterone in the blood plasma
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Collectively, these findings demonstrate that Tie2 + endothelial or hematopoietic cell GLP-1Rs are dispensable for the antiatherogenic actions of GLP-1RA, whereas Tie2-targeted GLP-1R + cells are required for a subset of the antiinflammatory actions of semaglutide in the liver
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