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The EXSCEL (NCT01144338), HARMONY (NCT02465515), REWIND ( NCT01394952), and AMPLITUDE-O (NCT03496298) trials all demonstrated cardioprotection or near misses for exenatide, albiglutide, dulaglutide and efpeglenatide, respectively
This may be due to carnitine's ability to keep blood glucose levels low even following a large carbohydrate meal
Leukemia 23(10):1755-1762, 2009
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The study found that liraglutide caused modest delays in gastric emptying, which slightly reduced peak concentrations (C_max) of some oral drugs but did not meaningfully alter total exposure (AUC)
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