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Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, et al

Particular concerns exist for those with: Type 2 diabetes or pre-diabetes , due to opposing and unpredictable glycaemic effects Cardiovascular disease , given the potential for heart rate changes and fluid retention associated with GH Active malignancy , as GH stimulation is contraindicated in this setting Pregnancy or breastfeeding neither agent should be used during pregnancy or whilst breastfeeding

and long-term outcomes of patients continuing versus discontinuing GLP-1RAs perioperatively

AMYRs are heterodimers of the class B1 G protein-coupled receptor, calcitonin (CT) receptor (CTR), and receptor activity-modifying proteins (RAMPs) 6,7

Rattanaprasert et al., 2019)