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Correlation of clinical response with homocysteine reduction during therapy with reduced B vitamins in patients with MDD who are positive for MTHFR C677T or A1298C polymorphism: a randomized, doubleblind, placebocontrolled study
Continued improvement weeks 6 to 12
At Perfect B, protocol selection between these options follows from a clinical intake conversation, not a default recommendation
(Source 8) However, it's hard to say this benefit is due to the caffeine when coffee is very high in polyphenol antioxidant compounds, which are beneficial
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