10.3389/fimmu.2021.734229 16 CarvalhoA
SY: Visualization, Writing original draft, Writing review & editing, Conceptualization, Funding acquisition, Project administration
After each use, ensure the rubber stopper is clean and the cap is on, then return the vial to refrigerated storage
Gall bladder/bile duct disease Acute pancreatitis and other pancreatic disorders have been reported, though the relationship to treatment is unclear Injection-site reactions Dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist Primary mechanism(s) of action Selectively binds and activates both GIP and GLP-1 receptors Example Tirzepatide (Mounjaro) Dosage Initial: 2.5 mg subcutaneous injection once weekly, titrated up to 5 mg weekly after 4 weeks If additional glycemic control is needed, dosage can be increased in 2.5 mg increments after at least 4 weeks on the current dosage
The global burden of diabetes and its complications: an emerging pandemic